Centrifugal spray drying biodegradable polymer as the target is based on the biodegradable polymer polylactic acid (PLA) and its copolymer polylactide-co-ethyl (PLGA) have been successfully sprayed with the small spray dryer B-290. The process parameter is to find that the prepared spherical particles have a smooth or structured surface.
The spray technology of the centrifugal spray dryer is a successful pharmaceutical employment method to prepare a microbead controlled drug delivery system. Other commonly used methods to produce microspheres are solvent emulsification evaporation, emulsification solvent extraction, or phase separation. Among these methods, spray drying is a simple, fast, reproducible and easy to scale up technique. It is a staged process, which enables light temperature conditions. Spray drying technology is less dependent on the solubility of the drug (for example, hydroelectric solubility) and polymer.